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| Model | Years | Speeds | Drive Train | Trans Model |
| Silverado 2500 | 1998-2003 | 4 Spd | RWD, 4WD 4.3L, 4.8L, 5.0L, 5.3L, 5.7L, 6.0L | 4L60E |
| Silverado 2500 | 2000-03 | 4 Spd | 6.5 Diesel | 4L80E |
| Silverado 2500 | 2000-03 | 5 Spd | 8.1L, 6.6L Diesel | ALLISON 1000 |
| Silverado 2500 | 2000-07 | 4 Spd | RWD, 4WD 5.7L, 6.0L, 7.4L, 8.1 L | 4L80E |
| Silverado 2500 , 2500HD | 2004-05 | 5 Spd | 8.1L, 6.6L Diesel | ALLISON 1000 |
| Silverado 2500 , 2500HD | 2004-07 | 4 Spd | 6.0L | 4L80E, LQ4 |
| Silverado 2500 , 2500HD | 2006-10 | 6 Spd | 8.1 L, 6.6L Diesel | ALLISON 1000 |
| Silverado 2500 , 2500HD | 2007-10 | 6 Spd | 6.0L | 6L90, LY6, L96 |